Target Selection
Identify a gene or genomic region relevant to the biological question being investigated.
Genetically Engineered Rat Models
Knockout Rat Models for Biomedical & Preclinical Research
Explore knockout rats, CRISPR-engineered rat models, transgenic models and genetically modified research rats for gene-function studies, disease modeling and biomedical research.
Gene-Edited Rat Model
Targeted genetic modification
TARGET GENE
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Target
Gene selection
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Edit
Genome modification
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Model
Research phenotype
Gene Knockout
Targeted disruption
CRISPR Editing
Genome engineering
MODEL DISCOVERY
Find a rat model for your research
Browse genetically engineered rat models by gene, model type, research application or catalog number.
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Search Models
RESEARCH MODELS
Explore genetically engineered rat models
Discover model types used to investigate gene function, biological pathways, disease mechanisms and preclinical research questions.
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Knockout Rat Models
Rat models in which a selected gene has been disrupted to investigate its biological function.
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CRISPR Rat Models
Genome-edited rat models generated through targeted CRISPR-based genetic modification.
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Transgenic Rat Models
Genetically engineered rats containing introduced genetic sequences for defined research applications.
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Disease Models
Research rat models used to investigate biological mechanisms associated with disease.
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Gene Function Models
Investigate how individual genes contribute to physiological processes and molecular pathways.
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Preclinical Research Models
Rat models relevant to experimental studies performed before clinical-stage investigation.
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GENETIC MODELING
What is a knockout rat?
A knockout rat is a genetically engineered rat in which a specific gene has been disrupted or functionally inactivated.
By comparing a knockout model with an appropriate control, researchers can investigate how loss of a particular gene influences physiology, development, molecular pathways or disease-associated phenotypes.
Genome-editing technologies such as CRISPR can support targeted genetic modification and the generation of specialized rat models for biomedical research.
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Reference Gene
Knockout Model
Reference genetic architecture
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Gene Disruption
Targeted loss-of-function model
MODEL CONCEPT
From target gene to research model
Gene-edited animal research begins with a biological question and a defined genetic target, followed by model characterization and phenotype investigation.
Genetic Modification
Generate a defined genetic change using an appropriate genome-engineering strategy.
Model Characterization
Confirm the intended genotype and evaluate relevant model characteristics.
Phenotype Research
Investigate biological consequences associated with the engineered genetic change.
BIOMEDICAL RESEARCH
Why are rat models used in biomedical research?
Rats are established experimental models in multiple areas of biomedical research. Their physiological, behavioral and anatomical characteristics can support studies in disease biology, pharmacology, neuroscience, metabolism and other research fields.
Explore Rat ModelsGene Function
Investigate the biological consequences of altering specific genes.
Disease Modeling
Study biological pathways and phenotypes relevant to disease research.
Pharmacology
Support experimental research involving drug response and biological mechanisms.
Preclinical Studies
Enable controlled investigation of biological questions in experimental research models.
MODEL SELECTION
Key information when selecting a rat model
Model selection should consider the engineered gene, genetic modification, background, phenotype and experimental research objective.
Target Gene
Confirm that the engineered gene corresponds to the molecular pathway or biological question being investigated.
Browse models →Genetic Modification
Review whether the model represents a knockout, transgenic or other genetically engineered configuration.
Browse models →Genetic Background
Genetic background can influence biological characteristics and experimental interpretation.
Browse models →Research Application
Select a model whose biological characteristics are appropriate for the intended study.
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QUESTIONS & ANSWERS
Knockout rat FAQ
Quick answers to common questions about knockout rats, CRISPR rat models and genetically engineered research animals.
Browse ModelsA knockout rat is a genetically engineered rat in which a selected gene has been disrupted or functionally inactivated. Such models can be used to investigate gene function and biological phenotypes.
A CRISPR knockout rat is a genetically engineered rat model in which CRISPR-based genome editing has been used to disrupt a defined gene or genomic region.
A knockout model generally involves disruption or inactivation of a gene, whereas a transgenic model commonly contains introduced genetic material. The exact design depends on the research objective.
Rat models are used across biomedical research because their physiology, behavior and body size can support experimental approaches relevant to disease mechanisms and preclinical studies.
Browse the Knockout Rat catalog using a gene name, model name, research application or catalog number.
RESEARCH MODELS
Browse Rat Models
Find a knockout rat model for your research
Explore genetically engineered rat models by gene, model type, application or catalog number.